LRP1-mediated pH-sensitive polymersomes facilitate combination therapy of glioblastoma in vitro and in vivo

Abstract Background Glioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment one of daunting challenges in oncology. The blood–brain barrier (BBB) main obstacle that prevents delivery potentially active therapeutic compounds. In this study, a new type pH-sensitive polymersomes has been designed for glioblastoma therapy to achieve combination radiotherapy chemotherapy U87-MG human xenografts nude mice significantly increased survival time. Results Au-DOX@PO-ANG good ability cross target tumors. This system pH-sensitivity respond tumor microenvironment. Gold nanoparticles doxorubicin are as complex drug. drug improve (RT) effect glioblastoma. treated with NPs have significant reduction volume. Conclusion summary, was fabricated BBB-traversing represents novel approach effects tumors provides hope treatment.